Paul Huber

Professor Emeritus


RNA expression and transport in Xenopus oocytes; developmental proteomics; the role of SUMOylation in heart development.


Principles of Biochemistry


Paul Huber earned his B.S. degrees in biology and chemistry at Boston College that included undergraduate research on the enzyme dihydrofolate reductase. He did his Ph.D. work on fast reaction enzyme kinetics at Purdue University. This was followed by postdoctoral work at The University of Chicago, where he developed a rapid technique to identify protein binding sites on RNA. He was a professor in the Department of Chemistry and Biochemistry at the University of Notre Dame for 37 years where his research focused mainly on a continuing interest in RNA biology.


Yang, C; Dominique, G. M; Champion, M. M.; Huber, Paul W.; Remnants of the Balbiani body are
required for formation of RNA transport granules in Xenopus oocytes. (2022) iScience, 25:3
Bertke, M. M.; Dubiak,K. M.; Cronin, L.; Zeng, E.; Huber, P. W.; A deficiency in SUMOylation activity
disrupts multiple pathways leading to neural tube and heart defects in Xenopus embryos. (2019) BMC
, 20: 386

Peuchen, E. H.; Cox, O. F.; Sun, L.; Hebert, A. S.; Coon, J. J.; Champion, M. M.; Dovichi, N. J.; Huber, P.
W.; Phosphorylation dynamics dominate the regulated proteome during early Xenopus development.
(2017) Scientific Reports 7:1

Sun, L.; Bertke, M. M.; Champion, M. M; Zhu, G.; Huber, P. W.; Dovichi, N. J.; Quantitative proteomics of
Xenopus laevis embryos: expression kinetics of nearly 4000 proteins during early development. (2014)
Scientific Reports, 4: 4365